Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.

ABSTRACT: Factor V Leiden (F5^L ) is a common genetic risk factor for venous thromboembolism in humans. We conducted a sensitized N-ethyl-N-nitrosourea (ENU) mutagenesis screen for dominant thrombosuppressor genes based on perinatal lethal thrombosis in mice homozygous for F5^L (F5^L/L ) and haploinsufficient for tissue factor pathway inhibitor (Tfpi^+/- ). F8 deficiency enhanced the survival of F5^L/LTfpi^+/- mice, demonstrating that F5^L/LTfpi^+/- lethality is genetically suppressible. ENU-mutagenized F5^L/L males and F5^L/+Tfpi^<

SUBMITTER: Westrick RJ 

PROVIDER: S-EPMC5594664 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature