Bone-Inspired Spatially Specific Piezoelectricity Induces Bone Regeneration.

ABSTRACT: The extracellular matrix of bone can be pictured as a material made of parallel interspersed domains of fibrous piezoelectric collagenous materials and non-piezoelectric non-collagenous materials. To mimic this feature for enhanced bone regeneration, a material made of two parallel interspersed domains, with higher and lower piezoelectricity, respectively, is constructed to form microscale piezoelectric zones (MPZs). The MPZs are produced using a versatile and effective laser-irradiation technique in which K_0.5Na_0.5NbO₃ (KNN) ceramics are selectively irradiated to achieve microzone phase transitions. The phase structure of the laser-irradiated microzones is changed from a mixture of orthorhombic and tetragonal phases (with higher piezoelectricity) to a tetr

SUBMITTER: Yu P 

PROVIDER: S-EPMC5595139 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature