Ontology highlight
ABSTRACT:
SUBMITTER: Kamphorst AO
PROVIDER: S-EPMC5595217 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20170309 6332
Programmed cell death-1 (PD-1)-targeted therapies enhance T cell responses and show efficacy in multiple cancers, but the role of costimulatory molecules in this T cell rescue remains elusive. Here, we demonstrate that the CD28/B7 costimulatory pathway is essential for effective PD-1 therapy during chronic viral infection. Conditional gene deletion showed a cell-intrinsic requirement of CD28 for CD8 T cell proliferation after PD-1 blockade. B7-costimulation was also necessary for effective PD-1 ...[more]