Associations Between Vitamin D Intake and Progression to Incident Advanced Age-Related Macular Degeneration.

ABSTRACT:

Purpose

There is growing evidence of the importance of nutrition in age-related macular degeneration (AMD), but no prospective studies have explored the impact of vitamin D. We evaluated the association between vitamin D intake and progression to advanced AMD.

Methods

Among 2146 participants (3965 eyes), 541 (777 eyes) progressed from early or intermediate AMD to advanced disease (mean follow-up: 9.4 years) based on ocular imaging. Nutrients were log transformed and calorie adjusted. Survival analysis was used to assess associations between incident advanced disease and vitamin D intake. Neovascular disease (NV) and geographic atrophy (GA) were evaluated separately. Combined effects of dietary vitamin D and calcium were assessed based on high or low consumption of each nutri

SUBMITTER: Merle BMJ 

PROVIDER: S-EPMC5595226 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature