Neoatherosclerosis development following bioresorbable vascular scaffold implantation in diabetic and non-diabetic swine.

ABSTRACT:

Background

DM remains a risk factor for poor outcome after stent-implantation, but little is known if and how DM affects the vascular response to BVS.

Aim

The aim of our study was to examine coronary responses to bioresorbable vascular scaffolds (BVS) in swine with and without diabetes mellitus fed a 'fast-food' diet (FF-DM and FF-NDM, respectively) by sequential optical coherence tomography (OCT)-imaging and histology.

Methods

Fifteen male swine were evaluated. Eight received streptozotocin-injection to induce DM. After 9 months (M), 32 single BVS were implanted in epicardial arteries with a stent to artery (S/A)-ratio of 1.1:1 under quantitative coronary angiography (QCA) and OCT guidance. Lumen, scaffold, neointimal coverage and composition were assessed by QCA, OC

SUBMITTER: van Ditzhuijzen NS 

PROVIDER: S-EPMC5595285 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature