Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct.

ABSTRACT: In order to translate preclinical data into the clinical studies, relevant in vitro models with structure and key functional properties similar to native human tissue should be used. In vitro cardiac models with vascular structures mimic the highly vascularized myocardium and provide interactions between endothelial cells, stromal cells and cardiomyocytes. Currently, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have been shown to present immature morphology and fetal-like electrophysiological properties that may limit their use as physiological test platform. The aim of this study was to develop multicellular in vitro cardiovascular construct modeling human heart tissue. In the cardiovascular construct, hPSC-CMs were cultured with a vascular-like network formed by human fo

SUBMITTER: Vuorenpaa H 

PROVIDER: S-EPMC5595750 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature