Using the affective bias test to predict drug-induced negative affect: implications for drug safety.

ABSTRACT:

Background and purpose

Predicting the risk of drug-induced adverse psychiatric effects is important but currently not possible in non-human species. We investigated whether the affective bias test (ABT) could provide a preclinical method with translational and predictive validity.

Experimental approach

The ABT is a bowl-digging task, which quantifies biases associated with learning and memory. Rats encounter independent learning experiences, on separate days, under either acute manipulations (e.g. pro-depressant vs. control) or different absolute reward values (e.g. high vs. low). A bias is observed during a preference test when an animal's choices reflect their prior experience. We investigated the effects of putative pro-depressant drug treatments following acute or chroni

SUBMITTER: Stuart SA 

PROVIDER: S-EPMC5595760 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature