Identification of key metabolic changes during liver fibrosis progression in rats using a urine and serum metabolomics approach.

ABSTRACT: Reversibility of hepatic fibrosis is an intrinsic response to chronic injury, and with on-going damage, fibrosis can progress to its end-stage consequence, cirrhosis. Non-invasive and reliable biomarkers for early detection of liver fibrosis are needed. Based on the CCl₄-induced liver fibrosis rat model, urinary and serum metabolic profiling performed by LC-QTOF-MS associated with histological progression were utilized to identify liver fibrosis-specific potential biomarkers for early prediction and to reveal significant fibrotic pathways and their dynamic changes in different stages of liver fibrosis. Finally, nine differential metabolites in urine and ten in serum were selected and identified involving the most relevant metabolic pathways. Perturbations of tryptophan, valine,

SUBMITTER: Chang H 

PROVIDER: S-EPMC5595818 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature