Spatio-temporal and dynamic regulation of neurofascin alternative splicing in mouse cerebellar neurons.

ABSTRACT: Alternative splicing is crucial for molecular diversification, which greatly contributes to the complexity and specificity of neural functions in the central nervous system (CNS). Neurofascin (NF) is a polymorphic cell surface protein that has a number of splicing isoforms. As the alternative splicing of the neurofascin gene (Nfasc) is developmentally regulated, NF isoforms have distinct functions in immature and mature brains. However, the molecular mechanisms underlying the alternative splicing of Nfasc in neurons are not yet understood. Here, we demonstrate that, alongside developmental regulation, Nfasc alternative splicing is spatially controlled in the mouse brain. We then identified distinct Nfasc splicing patterns at the cell-type level in the cerebellum, with Nfasc186 being expres

SUBMITTER: Suzuki S 

PROVIDER: S-EPMC5595909 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature