Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies.

ABSTRACT:

Aims

To investigate the safety of fluoxetine use during pregnancy, and to better understand the relationship between maternal fluoxetine use during the first trimester and congenital malformations in infants.

Methods

PubMed and Web of Science databases were systematically searched from inception to 21 March 2016. Additional studies were identified in a manual search of the reference lists. Two reviewers independently extracted data. A third reviewer checked the data. Estimates were pooled using a random-effects model to calculate the summarized relative ratios (RR) and 95% confidence intervals (CI).

Results

Among 1918 initially identified articles, 16 cohort studies were included. The offspring of pregnant women exposed to fluoxetine during the first trimester had a s

SUBMITTER: Gao SY 

PROVIDER: S-EPMC5595931 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature