Induction of oxidative metabolism by the p38α/MK2 pathway.

ABSTRACT: Adequate responses to environmental stresses are essential for cell survival. The regulation of cellular energetics that involves mitochondrial energy production and oxidative stress is central in the process of stress adaptation and response. The p38α signalling pathway plays a key role in the response to stress stimuli by orchestrating multiple cellular processes. However, prolonged activation of the p38α pathway results in impaired cell proliferation and can lead to cell death. Here we use a system to specifically activate p38α signalling and show that sustained activation of this pathway suffices to induce important metabolic changes, including high dependence on glucose for cell survival, increased consumption of glutamine, enhanced respiration rate and elevated production of mitochon

SUBMITTER: Trempolec N 

PROVIDER: S-EPMC5595987 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature