Metric to quantify white matter damage on brain magnetic resonance images.

ABSTRACT:

Purpose

Quantitative assessment of white matter hyperintensities (WMH) on structural Magnetic Resonance Imaging (MRI) is challenging. It is important to harmonise results from different software tools considering not only the volume but also the signal intensity. Here we propose and evaluate a metric of white matter (WM) damage that addresses this need.

Methods

We obtained WMH and normal-appearing white matter (NAWM) volumes from brain structural MRI from community dwelling older individuals and stroke patients enrolled in three different studies, using two automatic methods followed by manual editing by two to four observers blind to each other. We calculated the average intensity values on brain structural fluid-attenuation inversion recovery (FLAIR) MRI for the NAWM and W

SUBMITTER: Valdes Hernandez MDC 

PROVIDER: S-EPMC5596039 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature