Brain responses to vestibular pain and its anticipation in women with Genito-Pelvic Pain/Penetration Disorder.

ABSTRACT:

Objective

In DSM-5, pain-related fear during anticipation of vaginal penetration is a diagnostic criterion of Genito-Pelvic Pain/Penetration Disorder (GPPPD). We aimed to investigate subjective and brain responses during anticipatory fear and subsequent induction of vestibular pain in women with GPPPD.

Methods

Women with GPPPD (n = 18) and age-matched healthy controls (HC) (n = 15) underwent fMRI scanning during vestibular pain induction at individually titrated pain threshold after a cued anticipation period. (Pain-related) fear and anxiety traits were measured with questionnaires prior to scanning, and anticipatory fear and pain intensity were rated during scanning using visual analog scales.

Results

Women with GPPPD reported significantly higher levels of anticipat

SUBMITTER: Pazmany E 

PROVIDER: S-EPMC5596304 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature