Mimicking the Bioactivity of Fibroblast Growth Factor-2 Using Supramolecular Nanoribbons.

ABSTRACT: Fibroblast growth factor (FGF-2) is a multifunctional growth factor that has pleiotropic effects in different tissues and organs. In particular, FGF-2 has a special role in angiogenesis, an important process in development, wound healing, cell survival, and differentiation. Therefore, incorporating biological agents like FGF-2 within therapeutic biomaterials is a potential strategy to create angiogenic bioactivity for the repair of damaged tissue caused by trauma or complications that arise from age and/or disease. However, the use of growth factors as therapeutic agents can be costly and does not always bring about efficient tissue repair due to rapid clearance from the targeted site. An alternative would be a stable supramolecular nanostructure with the capacity to activate the FGF-2 rec

SUBMITTER: Rubert Perez CM 

PROVIDER: S-EPMC5596412 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature