Ned-19 inhibition of parasite growth and multiplication suggests a role for NAADP mediated signalling in the asexual development of Plasmodium falciparum.

ABSTRACT:

Background

Although malaria is a preventable and curable human disease, millions of people risk to be infected by the Plasmodium parasites and to develop this illness. Therefore, there is an urgent need to identify new anti-malarial drugs. Ca²⁺ signalling regulates different processes in the life cycle of Plasmodium falciparum, representing a suitable target for the development of new drugs.

Results

This study investigated for the first time the effect of a highly specific inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP)-induced Ca²⁺ release (Ned-19) on P. falciparum, revealing the inhibitory effect of this compound on the blood stage development of this parasite. Ned-19 inhibits both the transition of the parasite from the early to th

SUBMITTER: Suarez-Cortes P 

PROVIDER: S-EPMC5596470 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature