Amyloid-independent atrophy patterns predict time to progression to dementia in mild cognitive impairment.

ABSTRACT:

Background

Amyloid pathology in subjects with mild cognitive impairment (MCI) is an important risk factor for progression to dementia due to Alzheimer's disease. Predicting the onset of dementia is challenging even in the presence of amyloid, as time to progression varies considerably among patients and depends on the onset of neurodegeneration. Survival analysis can account for variability in time to event, but has not often been applied to MRI measurements beyond singular predefined brain regions such as the hippocampus. Here we used a voxel-wise survival analysis to identify in an unbiased fashion brain regions where decreased gray matter volume is associated with time to dementia, and assessed the effects of amyloid on these associations.

Methods

We included 276 subjects

SUBMITTER: Ten Kate M 

PROVIDER: S-EPMC5596472 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature