Altered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responses.

ABSTRACT: Aging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of marginal zone B lymphocytes (MZ, CD19⁺CD45R⁺CD21⁺⁺CD23^lo) and a decrease of naive B cells (CD19⁺IgD⁺), whereas there is an enhancement of a CD19⁺CD45R^lo innate-like B cell population (B1REL) and the so-called aged B cell compartment (ABC, CD45R⁺CD21^loCD23^loCD5^-CD11b^-) in aged senescence-accelerated (SAMP8) mice but not in aged senescence-resistant (SAMR1) mice. These changes in aged SAMP8 mice were associate

SUBMITTER: Cortegano I 

PROVIDER: S-EPMC5596542 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature