Increased tumor-infiltrating CD45RA^-CCR7^- regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress.

ABSTRACT: Regulatory T cells (Tregs) are major components of tumor-infiltrating immune cells with potent immunosuppressive properties in gastric cancer (GC) microenvironment. However, different subsets of the Tregs and their relevance to GC are unknown. Here, we found that patients with GC showed a significantly higher Tregs infiltration in tumors, and CD45RA^-CCR7^- Treg subset constituted most tumor-infiltrating Tregs. Tumor-infiltrating CD45RA^-CCR7^- Treg subset with an effector/memory phenotype accumulated in tumors and expressed low level of HLA-DR. Gastric tumor-derived TNF-α induced CD45RA^-CCR7^- Treg subset with similar phenotype to their status in tumors and inhibited their HLA-DR expression via activating STAT3 phosphorylation.

SUBMITTER: Mao FY 

PROVIDER: S-EPMC5596574 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature