Breast Milk Transforming Growth Factor β Is Associated With Neonatal Gut Microbial Composition.

ABSTRACT:

Background and objectives

Breast milk is a complex bioactive fluid that varies across numerous maternal and environmental conditions. Although breast-feeding is known to affect neonatal gut microbiome, the milk components responsible for this effect are not well-characterized. Given the wide range of immunological activity breast milk cytokines engage in, we investigated 3 essential breast milk cytokines and their association with early life gut microbiota.

Methods

A total of 52 maternal-child pairs were drawn from a racially diverse birth cohort based in Detroit, Michigan. Breast milk and neonatal stool specimens were collected at 1-month postpartum. Breast milk transforming growth factor (TGF)β1, TGFβ2, and IL-10 were assayed using enzyme-linked immunosorbent assays, where

SUBMITTER: Sitarik AR 

PROVIDER: S-EPMC5596927 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature