Regulatory network changes between cell lines and their tissues of origin.

ABSTRACT:

Background

Cell lines are an indispensable tool in biomedical research and often used as surrogates for tissues. Although there are recognized important cellular and transcriptomic differences between cell lines and tissues, a systematic overview of the differences between the regulatory processes of a cell line and those of its tissue of origin has not been conducted. The RNA-Seq data generated by the GTEx project is the first available data resource in which it is possible to perform a large-scale transcriptional and regulatory network analysis comparing cell lines with their tissues of origin.

Results

We compared 127 paired Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs) and whole blood samples, and 244 paired primary fibroblast cell lines and skin samples

SUBMITTER: Lopes-Ramos CM 

PROVIDER: S-EPMC5596945 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature