Histological assessment of granulomas in natural and experimental Schistosoma mansoni infections using whole slide imaging.

ABSTRACT: The pathology of schistosomiasis mansoni, a neglected tropical disease of great clinical and socioeconomic importance, results from the parasite eggs that become trapped in host tissues, particularly in the liver and intestines. Continuous antigenic stimulation from these eggs leads to recruitment of inflammatory cells to the sites of infection with formation of periovular granulomas. These complex structures have variable size and composition and are the most striking histopathological feature of schistosomiasis mansoni. However, evaluation of granulomas by conventional microscopy methods is time-consuming and limited, especially in large-scale studies. Here, we used high resolution Whole Slide Imaging (WSI), which allows fast scanning of entire histological slides, and multiple morphomet

SUBMITTER: Amaral KB 

PROVIDER: S-EPMC5597217 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature