Risk of myeloid neoplasms after radiotherapy among older women with localized breast cancer: A population-based study.

ABSTRACT:

Background

There are inconsistent and limited data regarding the risk of myeloid neoplasms (MN) among breast cancer survivors who received radiotherapy (RT) in the absence of chemotherapy. Concern about subsequent MN might influence the decision to use adjuvant RT for women with localized disease. As patients with therapy-related MN have generally poor outcomes, the presumption of subsequent MN being therapy-related could affect treatment recommendations.

Methods

We used the Surveillance, Epidemiology, and End Results (SEER)-Medicare linked database to study older women with in-situ or stage 1-3 breast cancer diagnosed 2001-2009 who received surgery. Chemotherapy and RT were ascertained using Medicare claims, and new MN diagnoses were captured using both SEER registry and Me

SUBMITTER: Zeidan AM 

PROVIDER: S-EPMC5597231 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature