Extrusion-based 3D printing of poly(propylene fumarate) scaffolds with hydroxyapatite gradients.

ABSTRACT: The primary focus of this work is to present the current challenges of printing scaffolds with concentration gradients of nanoparticles with an aim to improve the processing of these scaffolds. Furthermore, we address how print fidelity is related to material composition and emphasize the importance of considering this relationship when developing complex scaffolds for bone implants. The ability to create complex tissues is becoming increasingly relevant in the tissue engineering community. For bone tissue engineering applications, this work demonstrates the ability to use extrusion-based printing techniques to control the spatial deposition of hydroxyapatite (HA) nanoparticles in a 3D composite scaffold. In doing so, we combined the benefits of synthetic, degradable polymers, such as poly

SUBMITTER: Trachtenberg JE 

PROVIDER: S-EPMC5597446 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature