Myxoid fibroadenomas differ from conventional fibroadenomas: a hypothesis-generating study.

ABSTRACT:

Aims

Breast myxoid fibroadenomas (MFAs) are characterized by a distinctive hypocellular myxoid stroma, and occur sporadically or in the context of Carney complex, an inheritable condition caused by PRKAR1A-inactivating germline mutations. Conventional fibroadenomas (FAs) are underpinned by recurrent MED12 mutations in the stromal components of the lesions. The aim of this study was to investigate the genomic landscape of MFAs and compare it with that of conventional FAs.

Methods and results

Eleven MFAs from patients without clinical and/or genetic evidence of Carney complex were retrieved. DNA samples of tumour and matching normal tissue were subjected to massively parallel sequencing using the Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targe

SUBMITTER: Lozada JR 

PROVIDER: S-EPMC5597459 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature