Autoimmune hepatitis: Standard treatment and systematic review of alternative treatments.

ABSTRACT: Autoimmune hepatitis is a rare chronic inflammatory liver disease, affecting all ages, characterised by elevated transaminase and immunoglobulin G levels, positive autoantibodies, interface hepatitis at liver histology and good response to immunosuppressive treatment. If untreated, it has a poor prognosis. The aim of this review is to summarize the evidence for standard treatment and to provide a systematic review on alternative treatments for adults and children. Standard treatment is based on steroids and azathioprine, and leads to disease remission in 80%-90% of patients. Alternative first line treatment has been attempted with budesonide or cyclosporine, but their superiority compared to standard treatment remains to be demonstrated. Second-line treatments are needed for patients not r

SUBMITTER: Terziroli Beretta-Piccoli B 

PROVIDER: S-EPMC5597495 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature