Ketogenic diet poses a significant effect on imbalanced gut microbiota in infants with refractory epilepsy.

ABSTRACT:

Aim

To investigate whether patients with refractory epilepsy and healthy infants differ in gut microbiota (GM), and how ketogenic diet (KD) alters GM.

Methods

A total of 14 epileptic and 30 healthy infants were recruited and seizure frequencies were recorded. Stool samples were collected for 16S rDNA sequencing using the Illumina Miseq platform. The composition of GM in each sample was analyzed with MOTHUR, and inter-group comparison was conducted by R software.

Results

After being on KD treatment for a week, 64% of epileptic infants showed an obvious improvement, with a 50% decrease in seizure frequency. GM structure in epileptic infants (P1 group) differed dramatically from that in healthy infants (Health group). Proteobacteria, which had accumulated significantly i

SUBMITTER: Xie G 

PROVIDER: S-EPMC5597508 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature