Polyphenols journey through blood-brain barrier towards neuronal protection.

ABSTRACT: Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to influence hallmarks of neurodegenerative processes. In silico predictions and in vitro transport studies across blood-brain barrier (BBB) endothelial cells, at circulating concentrations, provided evidence for differential transport, likely related to chemical structure. Moreover, endothelial metabolism of these phenolic sulfates produced a plethora of novel chemical entities with further potential

SUBMITTER: Figueira I 

PROVIDER: S-EPMC5597593 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature