Thiopurine S-Methyltransferase Polymorphisms in Korean Dermatologic Patients.

ABSTRACT:

Background

Thiopurine S-methyltransferase (TPMT) is an important enzyme in the metabolism of thiopurines including azathioprine (AZA), 6-mercaptopurine, and 6-thioguanine. TPMT genotyping is widely used for screening of AZA-related toxicity during routine clinical practice in Korea. However, the data of TPMT genotypes and its AZA-related toxicity have not been studied in the field of dermatology.

Objective

The aim of this study was to evaluate the genetic basis of TPMT polymorphism in Korean dermatologic patients and subsequently to investigate the relationship between mutant TPMT and adverse responses to AZA treatment.

Methods

This study was retrospective, single-center study. One hundred forty-nine Korean dermatologic patients who underwent TPMT screening test were

SUBMITTER: Lee M 

PROVIDER: S-EPMC5597644 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature