Intracellular B Lymphocyte Signalling and the Regulation of Humoral Immunity and Autoimmunity.

ABSTRACT: B lymphocytes are critical for effective immunity; they produce antibodies and cytokines, present antigens to T lymphocytes and regulate immune responses. However, because of the inherent randomness in the process of generating their vast repertoire of antigen-specific receptors, B cells can also cause diseases through recognizing and reacting to self. Therefore, B lymphocyte selection and responses require tight regulation at multiple levels and at all stages of their development and activation to avoid diseases. Indeed, newly generated B lymphocytes undergo rigorous tolerance mechanisms in the bone marrow and, subsequently, in the periphery after their migration. Furthermore, activation of mature B cells is regulated through controlled expression of co-stimulatory receptors and intracell

SUBMITTER: Taher TE 

PROVIDER: S-EPMC5597704 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature