A Bayesian test for Hardy-Weinberg equilibrium of biallelic X-chromosomal markers.

ABSTRACT: The X chromosome is a relatively large chromosome, harboring a lot of genetic information. Much of the statistical analysis of X-chromosomal information is complicated by the fact that males only have one copy. Recently, frequentist statistical tests for Hardy-Weinberg equilibrium have been proposed specifically for dealing with markers on the X chromosome. Bayesian test procedures for Hardy-Weinberg equilibrium for the autosomes have been described, but Bayesian work on the X chromosome in this context is lacking. This paper gives the first Bayesian approach for testing Hardy-Weinberg equilibrium with biallelic markers at the X chromosome. Marginal and joint posterior distributions for the inbreeding coefficient in females and the male to female allele frequency ratio are computed, and us

SUBMITTER: Puig X 

PROVIDER: S-EPMC5597779 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature