Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial.

ABSTRACT:

Background

Many studies have reported an association between epilepsy, nodding syndrome (NS), and onchocerciasis (river blindness). A high prevalence of epilepsy has been noted particularly in onchocerciasis hyperendemic areas where onchocerciasis is not or insufficiently controlled with mass ivermectin distribution. There is evidence that increasing the coverage of ivermectin reduces the incidence of epilepsy, and anecdotal evidence suggests a reduction in seizure frequency in onchocerciasis-associated epilepsy (OAE) patients who receive ivermectin. Finding an alternative treatment for epilepsy in these patients will have major consequences.

Objective

The goal of the study is to assess whether ivermectin treatment decreases the frequency of seizures and leads to seizure fre

SUBMITTER: Colebunders R 

PROVIDER: S-EPMC5597797 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature