High-precision registration between zebrafish brain atlases using symmetric diffeomorphic normalization.

ABSTRACT: Atlases provide a framework for spatially mapping information from diverse sources into a common reference space. Specifically, brain atlases allow annotation of gene expression, cell morphology, connectivity, and activity. In larval zebrafish, advances in genetics, imaging, and computational methods now allow the collection of such information brain-wide. However, due to technical considerations, disparate datasets may use different references and may not be aligned to the same coordinate space. Two recent larval zebrafish atlases exemplify this problem: Z-Brain, containing gene expression, neural activity, and neuroanatomical segmentations, was acquired using immunohistochemical stains, while the Zebrafish Brain Browser (ZBB) was constructed from live scans of fluorescent reporters in tr

SUBMITTER: Marquart GD 

PROVIDER: S-EPMC5597853 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature