Feasibility of detecting myocardial infarction in the sheep fetus using late gadolinium enhancement CMR imaging.

ABSTRACT:

Background

Late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) imaging has enabled the accurate assessment of myocardial infarction (MI). However, LGE CMR has not been performed successfully in the fetus, where it could be useful for animal studies of interventions to promote cardiac regeneration. We believe that LGE imaging could allow us to document the presence, extent and effect of MI in utero and would thereby expand our capacity for conducting fetal sheep MI research. We therefore aimed to investigate the feasibility of using LGE to detect MI in sheep fetuses.

Methods

Six sheep fetuses underwent a thoracotomy and ligation of a left anterior descending (LAD) coronary artery branch; while two fetuses underwent a sham surgery. LGE CMR was performed i

SUBMITTER: Duan AQ 

PROVIDER: S-EPMC5598048 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature