Protective effects of thymoquinone and l-cysteine on cadmium-induced reproductive toxicity in rats.

ABSTRACT: This study was conducted to investigate the possible protective role of thymoquinone (TQ) and l-cysteine on the reproductive toxicity of male rats induced by cadmium chloride (CdCl₂). Forty rats were divided into four even groups. The first group served as untreated control. The second, third and fourth groups received CdCl₂, CdCl₂ and TQ, and CdCl₂ and l-cysteine, respectively for 56 days. Cd exposure caused spermatological damage (decrease sperm count and motility and increased the rates of sperm abnormalities), decrease serum testosterone level and increased oxidative stress. Histological alterations were also observed in the form of vascular and cellular changes in CdCl₂ treated rats. The vascular changes were congestion of the blo

SUBMITTER: Sayed MM 

PROVIDER: S-EPMC5598095 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature