Comparative study of the cytotoxic and genotoxic potentials of zinc oxide and titanium dioxide nanoparticles.

ABSTRACT: Nanoparticles (NPs) of zinc oxide (ZnO) and titanium dioxide (TiO₂) are receiving increasing attention due to their widespread applications. The aim of this study was to evaluate the toxic effect of ZnO and TiO₂ NPs at different concentrations (50, 100, 250 and 500 ppm) and compare them with their respective salts using a battery of cytotoxicity, and genotoxicity parameters. To evaluate cytotoxicity, we have used human erythrocytes and for genotoxic studies human lymphocytes have been used as in vitro model species. Concentration dependent hemolytic activity to RBC's was obtained for both NPs. ZnO and TiO₂ NPs resulted in 65.2% and 52.5% hemolysis at 250 ppm respectively indicating that both are cytotoxic to human RBCs. Antioxidant enzymes assays wer

SUBMITTER: Khan M 

PROVIDER: S-EPMC5598137 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature