Modulatory effect of fibre-enriched cake on alloxan-induced diabetic toxicity in rat brain tissues.

ABSTRACT: Diabetes is a metabolic disorder characterized by hyperglycaemia and it is fast becoming a scourge in sub-Saharan Africa. The nutritional properties of developed fibre-enriched cake and its protective potential against diabetic induced neurotoxicity in rats were investigated. Fibre-enriched cake was developed from selected fruits and analysed for its nutritional and sensory attributes. Rats were induced with diabetes by a single intraperitoneal injection of alloxan and treated with the formulated cake. After 14 days treatment, the rats were sacrificed by cervical dislocation. Their brain tissues were accessed for reduced glutathione (GSH), catalase, superoxide dismutase (SOD) activities, protein content and lipid peroxidation as well as lipid profiles which cover for total cholesterol, tri

SUBMITTER: Erukainure OL 

PROVIDER: S-EPMC5598228 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature