Acute liver injury induced by low dose dimethylnitrosamine alters mediators of hepatic vascular flow.

ABSTRACT: Alterations in liver vascular tone play an important role in chronic liver disease. The hepatic stellate cell (HSC) and mediators such as nitric oxide (NO) and hydrogen sulfide (H₂S) have been implicated in regulation of vascular tone and intra-hepatic pressure. Though these have been studied in chronic liver damage, changes in response to acute liver injury induced by hepatotoxins such as dimethyl nitrosamine are not well understood. Liver injury was induced in mice by a single intra-peritoneal injection of dimethylnitrosamine (DMN), following which animals were sacrificed at 24, 48 and 72 h. Changes in vascular mediators such as NO and H₂S as well as stellate cell activation was then examined. It was found that a single low dose of DMN in mice is sufficient to induc

SUBMITTER: Jayakumar Amirtharaj G 

PROVIDER: S-EPMC5598280 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature