Anti-inflammatory potential of native Australian herbs polyphenols.

ABSTRACT: The anti-inflammatory potential of hydrophilic polyphenolic-rich extracts obtained from native Australian herbs: anise myrtle, lemon myrtle and Tasmannia pepper leaf, and a reference sample bay leaf, was evaluated using the lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 model. Pretreatment with all herbal extracts at non-cytotoxic concentrations reduced the LPS-induced protein levels of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Concomitant decrease in accumulation of their products, prostaglandin E₂ (PGE₂) and nitric oxide (NO), respectively, was observed. A suppression of LPS-induced expression of COX-2 and iNOS and decrease of NO and PGE₂ levels suggests potential anti-inflammatory prope

SUBMITTER: Guo Y 

PROVIDER: S-EPMC5598408 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature