Systemic inflammatory responses following welding inhalation challenge test.

ABSTRACT:

Aim

The aim of this study was to investigate inflammatory and respiratory responses to welding fume exposure in patients with suspected occupational asthma.

Methods

Sixteen patients referred to the Finnish Institute of Occupational Health underwent mild steel (MS) and stainless steel (SS) welding challenge tests, due to suspicion of OA. Platelet count, leucocytes and their differential count, hemoglobin, sensitive CRP, lipids, glucose and fibrinogen were analyzed in addition to interleukin (IL)-1β, IL-6, IL-8, TNF-α, endothelin-1, and E-selectin in plasma samples. Peak expiratory flow (PEF), forced expiratory volume in 1 min (FEV₁) and exhaled nitric oxide (NO) measurements were performed before and after the challenge test. Personal particle exposure was assessed

SUBMITTER: Kauppi P 

PROVIDER: S-EPMC5598409 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature