Can TiC nanoparticles produce toxicity in oral administration to rats?

ABSTRACT:

Background

Titanium carbide (TiC) is used for ceramic metal composites in several industries and is regarded as a nanomaterial for catalyst and battery applications. However, there are very few studies in regard to the toxicological potential of TiC nanoparticles (NPs).

Objective

To study the toxicodynamics and toxicokinetics of TiC NPs in Sprague Dawley rats in acute (24 h) and subacute (28 days) oral administrations. The acute doses were 0.5, 5, 50, 300 and 1000 mg kg^-1; the subacute doses were 0.5 and 50 mg kg^-1.

Results

Organ histopathological examination (esophagus, stomach, intestines, spleen, liver, and kidneys) indicates the absence of damage at all applied doses, in both assessments. In the acute administration, alkaline phosphatases inc

SUBMITTER: Laloy J 

PROVIDER: S-EPMC5598454 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature