Acute and subchronic toxicity of the antitumor agent rhodium (II) citrate in Balb/c mice after intraperitoneal administration.

ABSTRACT: This study aimed to investigate potential acute and subchronic toxicity of rhodium (II) citrate in female Balb/c mice after intraperitoneal injections. In the acute test, independent groups received five doses; the highest dose (107.5 mg/kg) was equivalent to 33 times that used in our previous reports. The other doses were chosen as proportions of the highest, being 80.7 (75%), 53.8 (50%), 26.9 (25%) or 13.8 mg/kg (12.5%). Animals were monitored over 38 days and no severe signs of toxicity were observed, according to mortality, monitoring of adverse symptoms, hematological, biochemical and genotoxic parameters. We conclude that the median lethal dose (LD₅₀) could be greater than 107.5 mg/kg. In the subchronic test, five doses of Rh₂Cit (80, 60, 40, 20 or 10 mg/kg) wer

SUBMITTER: Carneiro MLB 

PROVIDER: S-EPMC5598461 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature