Prohexadione, a plant growth regulator, inhibits histone lysine demethylases and modulates epigenetics.

ABSTRACT:

Background

Epigenetic modifications, particularly DNA methylation and posttranslational histone modifications regulate heritable changes in transcription without changes in the DNA sequence. Despite a number of studies showing clear links between environmental factors and DNA methylation, little is known about the effect of environmental factors on the recently identified histone lysine methylation. Since their identification numerous studies have establish critical role played by these enzymes in mammalian development.

Objectives

Identification of the Jumonji (Jmj) domain containing histone lysine demethylase have added a new dimension to epigenetic control of gene expression by dynamic regulation of histone methylation marks. The objective of our study was to evaluate the

SUBMITTER: Vavilala DT 

PROVIDER: S-EPMC5598483 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature