Ashwagandha (Withania somnifera) supercritical CO₂ extract derived withanolides mitigates Bisphenol A induced mitochondrial toxicity in HepG2 cells.

ABSTRACT: Bisphenol A (BPA) safety aspects on human health are debated extensively for long time. In the present study, we have studied the toxicity induced by BPA at no observed adverse effect level (NOAEL) using HepG2 cells. We report that BPA at 100 nM induced cytotoxicity to HepG2 cells as determined by MTT assay at 0-72 h. The toxicity was result of reduced oxygen consumption and reduced mitochondrial membrane potential associated with decreased ATP production. The BPA treatment resulted in increase of malondialdehyde (MDA) content with decreased glutathione and other antioxidant enzymes. BPA derived toxicity is a concern to human health and alternative non-toxic natural products/derivatives or adjuvants that serve as antidote will be relevant. In this context, Ashwagandha (Withania somnifer

SUBMITTER: Vidyashankar S 

PROVIDER: S-EPMC5598539 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature