Palladium-Catalyzed β-Arylation of α-Keto Esters.

ABSTRACT: A catalyst system derived from commercially available Pd₂(dba)₃ and P^tBu₃ has been applied to the coupling of α-keto ester enolates and aryl bromides. The reaction provides access to an array of β-stereogenic α-keto esters. When the air-stable ligand precursor P^tBu₃·HBF₄ is employed, the reaction can be carried out without use of a glovebox. The derived products are of broad interest given the prevalence of the α-keto acid substructure in biologically important molecules.

SUBMITTER: Zavesky BP 

PROVIDER: S-EPMC5598777 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature