Multicellular Transcriptional Analysis of Mammalian Heart Regeneration.

ABSTRACT:

Background

The inability of the adult mammalian heart to regenerate following injury represents a major barrier in cardiovascular medicine. In contrast, the neonatal mammalian heart retains a transient capacity for regeneration, which is lost shortly after birth. Defining the molecular mechanisms that govern regenerative capacity in the neonatal period remains a central goal in cardiac biology. Here, we assemble a transcriptomic framework of multiple cardiac cell populations during postnatal development and following injury, which enables comparative analyses of the regenerative (neonatal) versus nonregenerative (adult) state for the first time.

Methods

Cardiomyocytes, fibroblasts, leukocytes, and endothelial cells from infarcted and noninfarcted neonatal (P1) and adult (P56

SUBMITTER: Quaife-Ryan GA 

PROVIDER: S-EPMC5598916 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature