Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.

ABSTRACT:

Background

Myeloid cells are central to atherosclerotic lesion development and vulnerable plaque formation. Impaired ability of arterial phagocytes to uptake apoptotic cells (efferocytosis) promotes lesion growth and establishment of a necrotic core. The transcription factor interferon regulatory factor (IRF)-5 is an important modulator of myeloid function and programming. We sought to investigate whether IRF5 affects the formation and phenotype of atherosclerotic lesions.

Methods

We investigated the role of IRF5 in atherosclerosis in 2 complementary models. First, atherosclerotic lesion development in hyperlipidemic apolipoprotein E-deficient (ApoE^-/-) mice and ApoE^-/- mice with a genetic deletion of IRF5 (ApoE^-/-Irf5^-/-) was comp

SUBMITTER: Seneviratne AN 

PROVIDER: S-EPMC5598917 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature