Structural signatures of thermal adaptation of bacterial ribosomal RNA, transfer RNA, and messenger RNA.

ABSTRACT: Temperature adaptation of bacterial RNAs is a subject of both fundamental and practical interest because it will allow a better understanding of molecular mechanism of RNA folding with potential industrial application of functional thermophilic or psychrophilic RNAs. Here, we performed a comprehensive study of rRNA, tRNA, and mRNA of more than 200 bacterial species with optimal growth temperatures (OGT) ranging from 4°C to 95°C. We investigated temperature adaptation at primary, secondary and tertiary structure levels. We showed that unlike mRNA, tRNA and rRNA were optimized for their structures at compositional levels with significant tertiary structural features even for their corresponding randomly permutated sequences. tRNA and rRNA are more exposed to solvent but remain structured for

SUBMITTER: Jegousse C 

PROVIDER: S-EPMC5598986 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature