A novel panel of α-synuclein antibodies reveal distinctive staining profiles in synucleinopathies.

ABSTRACT: Synucleinopathies are a spectrum of neurodegenerative diseases characterized by the intracellular deposition of the protein α-synuclein leading to multiple outcomes, including dementia and Parkinsonism. Recent findings support the notion that across the spectrum of synucleinopathies there exist diverse but specific biochemical modifications and/or structural conformations of α-synuclein, which would give rise to protein strain specific prion-like intercellular transmission, a proposed model that could explain synucleinopathies disease progression. Herein, we characterized a panel of antibodies with epitopes within both the C- and N- termini of α-synuclein. A comprehensive analysis of human pathological tissue and mouse models of synucleinopathy with these antibodies support the notion that

SUBMITTER: Dhillon JS 

PROVIDER: S-EPMC5599040 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature