A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms.

ABSTRACT: Modelling ionic channels represents a fundamental step towards developing biologically detailed neuron models. Until recently, the voltage-gated ion channels have been mainly modelled according to the formalism introduced by the seminal works of Hodgkin and Huxley (HH). However, following the continuing achievements in the biophysical and molecular comprehension of these pore-forming transmembrane proteins, the HH formalism turned out to carry limitations and inconsistencies in reproducing the ion-channels electrophysiological behaviour. At the same time, Markov-type kinetic models have been increasingly proven to successfully replicate both the electrophysiological and biophysical features of different ion channels. However, in order to model even the finest non-conducting molecular confo

SUBMITTER: Balbi P 

PROVIDER: S-EPMC5599066 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature