Polygenic risk score analysis of pathologically confirmed Alzheimer disease.

ABSTRACT: Previous estimates of the utility of polygenic risk score analysis for the prediction of Alzheimer disease have given area under the curve (AUC) estimates of <80%. However, these have been based on the genetic analysis of clinical case-control series. Here, we apply the same analytic approaches to a pathological case-control series and show a predictive AUC of 84%. We suggest that this analysis has clinical utility and that there is limited room for further improvement using genetic data. Ann Neurol 2017;82:311-314.

SUBMITTER: Escott-Price V 

PROVIDER: S-EPMC5599118 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature